谢正伟副研究员、助理教授

联系方式xiezhengwei@ bjmu.edu.cn

研究方向：

实验室综合使用计算和实验方法，包括人工智能，分子细胞实验等，研究衰老和疾病的机制并进行创新药物研发，具体方向包括：

1. 基于人工智能的药物研发系统的开发

2. 衰老的分子机制和延长寿命的药物的开发

3. 癌症、肥胖、非酒精性肝炎、干细胞、痛风、骨质疏松等疾病方向的药物研发

个人简介：

谢正伟， 博士，北京大学国际癌症研究院、北京大学基础医学院副研究员、助理教授。主要应用交叉学科手段，包括人工智能和计算生物学方法，进行衰老和代谢疾病的机制研究和创新药物研发。主要的科研成果包括：1）开发出第一代衰老微流芯片并发现衰老标记蛋白HSP104；2）发现端粒酶失活的初始时期细胞即呈现早衰现象及其保护机制；3）发明了代谢网络中计算酶-流变化关系的的超立方收缩算法；4）发现小檗碱可以延长野生小鼠的寿命并揭示其分子机制；5）发现抑制乙酰转移酶Gcn5可以延长酵母和人细胞系的寿命；6）开发了基于深度学习和基因指纹的药效预测系统——灵素系统等。以第一作者/通讯作者（含并列）在Nature Biotechnology、Cell、Aging Cell、Bioinformatics、JCIM等杂志发表论文。研究工作曾被《自然》杂志“新闻与视角”栏目长文报道，获评2016中国医学科学研究年度十大进展，2021中国生物信息年度十大进展。主持国家重点研发计划子课题一项，国家自然科学基金面上项目二项，北京市面上项目一项。中国药理学会表观遗传分会委员，中国老年学和老年医学学会抗衰老分会委员。

代表性论文：

(1) Jie Zhu#, Jingxiang Wang#, Xin Wang#, Mingjing Gao#, Bingbing Guo#, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou,*, Ning Zhang*, Ruimao Zheng*, Zhengwei Xie* Prediction of Drug Efficacy from Transcriptional Profiles with Deep Learning  Nature biotechnology  2021,39:1444-1452 doi: 10.1038/s41587-021-00946-z

(2) Jie Zhu，Weikaixin Kong，Zhengwei Xie*, Expression and Prognostic Characteristics of Ferroptosis-related Gene in Colon Cancer,  Int. J. Mol. Sci.   2021, 22(11):5652. doi: 10.3390/ijms22115652.

(3) Yiming Wang#, Weikaixin Kong#, Liang Wang, Tianyu Zhang, Boyue Huang, Jia Meng, Baoxue Yang, Zhengwei Xie* and Hong Zhou* Multiple-purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis  Int. J. Mol. Sci.   2020, 21(20), 7695;   https://doi.org/10.3390/ijms21207695

(4) Weikaixin Kong#，Miaomiao Gao#, Yuchen Jin, Zhuo Huang*, Zhengwei Xie*, Prognostic model of patients with liver cancer based on tumor stem cell content and immune process,  Aging  ,  2020 (12) 16, 16555-16578.

(5) Weikaixin Kong#, Xinyu Tu#, Weiran Huang, Yang Yang, Zhengwei Xie*, Zhuo Huang* Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing,  J. Chem. Inf. Model.  May 18, 2020, 60（6）, 2739-2753 (doi:10.1021/acs.jcim.9b01180)

(6) Miaomiao Gao^#, Weikaixin Kong^#, Zhuo Huang*, Zhengwei Xie* Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis.  Int. J. Mol. Sci.  2020, 21(8), 2994 (doi:10.3390/ijms21082994)

(7) Yao Dang^#, Yongpan An^#, Jinzhao He, Boyue Huang, Jie Zhu, Miaomiao Gao, Shun Zhang, Xin Wang, Baoxue Yang* and Zhengwei Xie* Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.  Aging Cell  2020; 19:e13060

(8) Boyue Huang^#, Dandan Zhong^#, Jie Zhu, Yongpan An, Miaomiao Gao, Shuai Zhu, Weiwei Dang, Xin Wang, Baoxue Yang* and Zhengwei Xie* Inhibition of Histone Acetyltransferase GCN5 Extends Lifespan in both Yeast and Human Cell Lines.  Aging Cell 2020; 00:e13129 https://doi.org/10.l111/acel.13129

(9) Zhengwei Xie^#*, Tianyu Zhang^#, Qi Ouyang*, Genome-scale fluxes were predicted under the guidance of enzyme abundance using a novel Hyper-Cube Shrink Algorithm,  Bioinformatics , 2018.2.1, 34(3): 502~510

(10) Zhengwei Xie^#, Kyle Jay^#, Dana L. Smith, Yi Zhang, Zairan Liu, Jiashun Zheng, Ruilin Tian, Hao Li*, and Elizabeth Blackburn*, Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length  Cell , 2015, 160(5): 928-939

(11) Zhengwei Xie, Yi Zhang, Ke Zou, Onn Brandman, Chunxiong Luo, Qi Ouyang*, Hao Li*, Molecular Phenotyping of Aging in Single Yeast Cells Using a Novel Microfluidic Device,  Aging Cell  2012, (11): 599~606