Research
Abstract

Dr. Burg has made enormous contributions to nephrology in two important areas as follows.  His invented the  method of perfusion of isolated renal tubules , which forms the basis for the study of  kidney functionin health and disease. Also, his present studies of osmotic stress inform us of how cells in the renal inner medulla function despite the very high levels of salt and urea to which they are exposed. Based on these achievements he has received numerous awards and honors, including election to the National Academy of Sciences.

Publications

Dmitrieva NI, Cui K, Kitchaev DA, Zhao K, Burg MB. DNA double-strand breaks induced by high NaCl occur predominantly in gene deserts. Proc Natl Acad Sci U S A. 108(51):20796-801, 2011.

Zhou X, Ferraris JD, Dmitrieva NI, Liu Y, and Burg MB. MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: Opposite roles of p38α and p38?. Proc Natl Acad Sci USA 105:5620-5625, 2008.

Morgan G, Ferraris JD, Burg MB.  GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC. Proc Natl Acad Sci USA 105:11026-11031, 2008.