学术信息
特邀美国哥伦比亚大学顾伟教授和印第安纳大学卢华教授学术报告
发布日期：2007-12-06
学术报告 北京大学医学部特邀美国哥伦比亚大学顾伟教授 (Wei Gu) 和印第安纳大学的卢华（Hua Lu）教授来我院进行学术报告，他们在p53相关研究方面有着杰出的成就，在Nature、Cell、Science、Mol. Cell、Mol Cell Biol等高水平杂志发表论文数十篇。欢迎广大师生届时聆听与讨论！ 时间：2007年12月11日星期二，下午2：00—4：00 地点：北京大学医学部逸夫教学楼5楼 502室 （一）报告人：Wei Gu Ph.D. Professor Institute for Cancer Genetics，Herbert Irving Cancer Research Center，
College of Physicians & Surgeons，Columbia University . 报告题目："Dissecting the p53 tumor suppressor pathway" Selected Publications： 1. Luo, J, Su, F., Chen, D., Shiloh, A., and Gu, W. (2000) Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408, 377-381. 2. Guo, A., Salomoni, P., Luo, J., Shih, A., Zhong, S., Gu, W., and Pandolfi, P.P. (2000) Role of PML in p53-dependent apoptosis. Nature Cell Biol. 2, 730-736. 3. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., and Gu, W. (2001) Negative control of p53 by Sir2a promotes cell survival under stress. Cell. 107, 137-148. 4. Bereschenko, O. R., Gu, W., and Dalla-Favera, R. (2002) Acetylation inactivates the transcriptional repressor BCL-6. Nature Genetics, 32, 606-613. 5. Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., and Gu, W. (2002) Deubiquitination of p53 by HAUSP constitutes an important pathway for p53 stabilization. Nature. 416, 648-653 6. Nikolaev, A. Y., Li, M., Puskas, N., Qin, J., and Gu, W. (2003) Parc: a cytoplasmic anchor for p53. Cell. 112, 29-40. 7. Li, M., Chris, B., Wu-Baer, F., Chen, D., Bear, R., and Gu, W. (2003) Mono- vs. polyubiquitination: differential Control of p53 fate by MDM2. Science，2003; 302: 1972. 8. Li M, Brooks CL, Kon N, Gu W.(2004) A dynamic role of HAUSP in the p53-Mdm2 pathway.. Mol Cell. 2004 ;13(6):879-86. 9.Chen D, Kon N, Li M, Zhang W, Qin J, Gu W.(2005). ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor .Cell. 2005 ;121(7):963-5. 10.Tang Y, Luo J, Zhang W, Gu W（2006）Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell. 2006 ;24(6):807-8. （二）报告人：Hua Lu Ph.D. Professor Current address: Department of Biochemistry and Molecular Biology， Indiana University School of Medicine Previous address: Department of Biochemistry and Molecular Biology, Oregon Health Sciences University 报告题目: Non-translational roles of ribosomal proteins: Regulating p53 and c-Myc. Selected Publications： 1．Zeng X.Y, Li X, Miller A, Yuan Z, Yuan W, Kwok RP, Goodman R, Lu H. (2000) The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis. Mol Cell Biol. 20: 1299-310. 2．Kobet E, Zeng X, Zhu Y, Keller D and Lu H. (2000) MDM2 Inhibits p300-mediated p53 Acetylation and Activation by Forming a Ternary Complex with Two Proteins. Proc. Natl. Acad. Sci. USA. 97:12547-12552 4., 3．Keller D, Zeng XY, Wang Y, Zhang Q, Kapoor M, Zhao YM, Goodman R, Lozano G, and Lu H. (2001) A DNA damage responsive p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol. Cell. 7: 283. 4．Zeng SX, Dai MS, Keller D, and Lu H. (2002) SSRP1 functions as a co-activator of the transcriptional activator p63. EMBO J. 21, 5487-5497. Jin YT, Lee, HJ, Zeng SX, Dai, MS, and Lu H (2003) MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J. 22, 6365-6377. 5．Dai MS, Zeng SX, Jin YT, Sun XX, David L, and Lu H (2004). Ribosomal protein L23 activates p53 by abrogating MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol. Cell. Biol. 24, 7654-7668. . 6.Yu Y, Maggi Jr. LB, Kim H, Dai M-S, Lu H, and Weber JD. Nucleophosmin is a rate-limiting nuclear export factor for the ribosome. Mol. Cell. Biol.(2006) 7.Ding Y, Lee JF, Lu H, Lee MH, and Yan DH. Interferon-inducible IFIXa1, a novel HDM2-interacting protein, destabilizes HDM2 by promoting its ubiquitination. Mol. Cell. Biol. (2006) 8.Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H.(2006) 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 ;25(6):1207-18. 9.Dai MS, Arnold H, Sun XX, Sears R, Lu H. Inhibition of c-Myc activity by ribosomal protein L11. EMBO J. 2007 ;26(14):3332-45. 10.Jin YT, Zeng SX, Sun XX, Lee H, Blattner C, Xiao ZX, and Lu H. (2007) MDMX promote proteasomal turnover of p21 during cell cycle independently of, but in cooperation with, MDM2. Mol Cell. Biol. In press. 北京大学医学部 北京大学基础医学院 主办
College of Physicians & Surgeons，Columbia University . 报告题目："Dissecting the p53 tumor suppressor pathway" Selected Publications： 1. Luo, J, Su, F., Chen, D., Shiloh, A., and Gu, W. (2000) Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408, 377-381. 2. Guo, A., Salomoni, P., Luo, J., Shih, A., Zhong, S., Gu, W., and Pandolfi, P.P. (2000) Role of PML in p53-dependent apoptosis. Nature Cell Biol. 2, 730-736. 3. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., and Gu, W. (2001) Negative control of p53 by Sir2a promotes cell survival under stress. Cell. 107, 137-148. 4. Bereschenko, O. R., Gu, W., and Dalla-Favera, R. (2002) Acetylation inactivates the transcriptional repressor BCL-6. Nature Genetics, 32, 606-613. 5. Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., and Gu, W. (2002) Deubiquitination of p53 by HAUSP constitutes an important pathway for p53 stabilization. Nature. 416, 648-653 6. Nikolaev, A. Y., Li, M., Puskas, N., Qin, J., and Gu, W. (2003) Parc: a cytoplasmic anchor for p53. Cell. 112, 29-40. 7. Li, M., Chris, B., Wu-Baer, F., Chen, D., Bear, R., and Gu, W. (2003) Mono- vs. polyubiquitination: differential Control of p53 fate by MDM2. Science，2003; 302: 1972. 8. Li M, Brooks CL, Kon N, Gu W.(2004) A dynamic role of HAUSP in the p53-Mdm2 pathway.. Mol Cell. 2004 ;13(6):879-86. 9.Chen D, Kon N, Li M, Zhang W, Qin J, Gu W.(2005). ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor .Cell. 2005 ;121(7):963-5. 10.Tang Y, Luo J, Zhang W, Gu W（2006）Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell. 2006 ;24(6):807-8. （二）报告人：Hua Lu Ph.D. Professor Current address: Department of Biochemistry and Molecular Biology， Indiana University School of Medicine Previous address: Department of Biochemistry and Molecular Biology, Oregon Health Sciences University 报告题目: Non-translational roles of ribosomal proteins: Regulating p53 and c-Myc. Selected Publications： 1．Zeng X.Y, Li X, Miller A, Yuan Z, Yuan W, Kwok RP, Goodman R, Lu H. (2000) The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis. Mol Cell Biol. 20: 1299-310. 2．Kobet E, Zeng X, Zhu Y, Keller D and Lu H. (2000) MDM2 Inhibits p300-mediated p53 Acetylation and Activation by Forming a Ternary Complex with Two Proteins. Proc. Natl. Acad. Sci. USA. 97:12547-12552 4., 3．Keller D, Zeng XY, Wang Y, Zhang Q, Kapoor M, Zhao YM, Goodman R, Lozano G, and Lu H. (2001) A DNA damage responsive p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol. Cell. 7: 283. 4．Zeng SX, Dai MS, Keller D, and Lu H. (2002) SSRP1 functions as a co-activator of the transcriptional activator p63. EMBO J. 21, 5487-5497. Jin YT, Lee, HJ, Zeng SX, Dai, MS, and Lu H (2003) MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J. 22, 6365-6377. 5．Dai MS, Zeng SX, Jin YT, Sun XX, David L, and Lu H (2004). Ribosomal protein L23 activates p53 by abrogating MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol. Cell. Biol. 24, 7654-7668. . 6.Yu Y, Maggi Jr. LB, Kim H, Dai M-S, Lu H, and Weber JD. Nucleophosmin is a rate-limiting nuclear export factor for the ribosome. Mol. Cell. Biol.(2006) 7.Ding Y, Lee JF, Lu H, Lee MH, and Yan DH. Interferon-inducible IFIXa1, a novel HDM2-interacting protein, destabilizes HDM2 by promoting its ubiquitination. Mol. Cell. Biol. (2006) 8.Jin Y, Dai MS, Lu SZ, Xu Y, Luo Z, Zhao Y, Lu H.(2006) 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J. 2006 ;25(6):1207-18. 9.Dai MS, Arnold H, Sun XX, Sears R, Lu H. Inhibition of c-Myc activity by ribosomal protein L11. EMBO J. 2007 ;26(14):3332-45. 10.Jin YT, Zeng SX, Sun XX, Lee H, Blattner C, Xiao ZX, and Lu H. (2007) MDMX promote proteasomal turnover of p21 during cell cycle independently of, but in cooperation with, MDM2. Mol Cell. Biol. In press. 北京大学医学部 北京大学基础医学院 主办