学术信息
Molecular mechanisms of bile secretion and hereditary cholestasis
生理与病理生理学系及糖尿病中心学术活动
题 目：Molecular mechanisms of bile secretion and hereditary cholestasis
讲演人：Lin Wang, M.D., Ph.D.
Research Assistant Professor
Department of Molecular Biophysics and Biochemistry
The Liver Center
Yale University
时 间： 2008-4-24 （Thursday）2:00pm
地 点：生理楼三层会议室
Lin Wang, M.D., Ph.D.,
1985-1991, M.D., Beijing Medical University, Beijing, China ;
1993-1997, Ph.D. student, Department of Biochemistry, University of Bristol, U.K.
1997-1999, Postdoctoral Fellow, Center for Molecular Biology, University of Heidelberg, Germany .
1999-2004, Associate Research Scientist, Internal Medicine/the Liver Center , Yale University,
2004-Present, Independent group leader/Research Assistant Professor, Department of Molecular Biophysics and Biochemistry/The Liver Center, Yale University.
Selected Pulications:
1. Arteaga, M.F., Wang, L., Ravid, T., Hochstrasser, M. and Canessa C.M. (2006) An N-terminal degradation signal in serum and glucocorticoid-induced kinase (Sgk1) targets it to the ER-associated ubiquitin-conjugation machinery. PNAS, 103, 11178–11183.
2. Wang, L.* and Boyer, J.L. (2004) The maintenance and generation of membrane polarity in hepatocytes. Hepatology, 39, 892-899 (*corresponding author)
3. Wang, L.*, Soroka, C.J. and Boyer, J.L. (2002) The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type II. Journal of Clinical Investigation, 110, 965-972. (*corresponding author).
4. Cai, S.*, Wang L.*, Ballatori, N. and Boyer, J.L. (2001) The bile salt export pump, an ABC transporting polypeptide in liver, is highly conserved in vertebrate evolution and its expression is impaired by PFICII mutations. Am J Physiol Gastrointest Liver Physiol. 2001 281 G 316-322(*equal contribution)
5. Wang, L.* & Dobberstein B. (1999) Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. FEBS Lette. 457, 316-322 (*corresponding author)