北京大学基础医学院

院长论坛

报告题目：A novel KDM4 inhibitor controls triple-negative breast cancer stem cells.

报告人：Prof. Dr. Roland Schuele

Professor, Scientific Director, Dept. of Urology and Director, Center for Clinical Research

Freiburg University Medical Centre

Germany.

Speaker CRC 992 Medical Epigenetics.

时间：2017年6月28日（星期三）下午14:00

地点：生化楼三层中厅

主持人：细胞生物学系 杜晓娟 教授

 

报告人近年主要发表文章：

1.       Duteil, D., Tosic, M., Willmann, W., Georgiadi, A., Kanouni, T. and Schüle, R. (2017) Lsd1 prevents age-programed loss of beige adipocytes. Proc. Natl. Acad. Sci. USA, in press.

2.       Metzger E, Willmann D, McMillan J, Forne I, Petroll K, Metzger P, Gerhardt S, Maessenhausen A, Schott A-K, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O and Schüle R. Assembly of methylated LSD1 and CHD1 drives ARdependent transcription and translocation. Nat Struct Mol Biol., 23, 132-139, 2016.

3.       Duteil D, Metzger E, Willmann D, Karagianni P, Friedrichs N, Greschik H, Günther T, Buettner R, Talianidis I, Metzger D and Schüle R. LSD1 promotes oxidative metabolism of white adipose tissue. Nat Commun. 5, 4093, 2014

4.       Zhu D, H？lz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D,ünther T, Arnold SJ and Schüle R. Lsd1 regulates differentiation onset and migration of trophoblast stem cells. Nat. Commun. 5, 3174-3184, 2014.

5.       Metzger E, Imhof A, Patel D, Kahl K, Hoffmeyer K, Friedrichs F, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R and Schüle R. Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4. Nature464, 792-796, 2010.

6.       Metzger E, Wissmann M, Yin N, Müller JM, Schneider R, Peters HFM, Günther T, Buettner R and Schüle R. LSD1 demethylates repressive histone marks to promote androgen receptor dependent transcription. Nature 437, 436-439, 2005. 

 

 

欢迎各位老师及同学参加！