北京大学基础医学院

院长论坛

 

报告题目：Mechanisms of Epigenetic Plasticity in Stem Cells and Cancer

报告人： Thea Tlsty  Ph.D.  

Professor of Pathology, UCSF, USA

时  间： 2010年7月8日 (星期四)上午10：30

地  点：医学部逸夫教学楼409教室

主持人： 尹玉新教授

 

报告人简介：

Dr.Thea Tlsty is a Professor in the Department of Pathology, Director of the Program in Cell Cycling and Signaling in the UCSF Comprehensive Cancer Center and Director of the Center for Translational Research in the Molecular Genetics of Cancer at the University of California, San Francisco, School of Medicine, San Francisco, CA . She received a Ph.D. in Molecular Biology from Washington University .   Dr. Tlsty trained with Dr. Robert Schimke at Stanford University as a Postdoctoral Fellow and Senior Research Associate in the Department of Biological Sciences before she was recruited to the University of North Carolina as Assistant Professor of Pathology and Member of the UNC Lineberger Comprehensive Cancer Center . In 1994 she joined the faculty at UCSF.

Dr. Tlsty studies genetic, epigenetic and functional changes involved in the earliest steps of epithelial cancers and how interactions between stromal components and epithelial cells collaborate to moderate carcinogenesis. Her research studies of human epithelial cells from healthy individuals are providing novel insights into how early molecular events affect genomic integrity and fuel carcinogenesis. Prior work from her laboratory has shown that surrounding stroma can dramatically influence tumorigenesis. She investigates how these changes are initiated and moderated, as well as their consequences for clinical disease. These insights are applied in risk assessment, early detection, and prognostic studies.

Honors and Awards

1st Gerald Wogan Distinguished Lectureship,Boston,MA., 1997, Distinguished Lecture Series, Harvard School of Public Health,1998, 8th Annual Corpus Ortigoza Distinguished Lectureship, Houston, Tx., 1998, Meyenburg-Stiftung Honorary Lectureship, Heidleberg, Germany, 2002, elected Fellow of AAAS (2001), NCI Knudson Award, 2003, Distinguished Lecture in Molecular Medicine, University of Toronto, 2004, Olof Pearson Lecture, Cleveland, OH, 2005, NIH, Prestigious Lecture Series, Bethesda, MD, 2006, Robert S. Harris Lecture, Massachusetts Institute of Technology, 2006, Frank Townsend Lecture, UT Heath Science Center, San Antonio, Tx, 2009, Julia and Patricia Kingsbury Memorial Lectureship, Yale Cancer Center, New Haven, CT, 2010