报告人：Zihai Li, M.D.; Ph.D

l        Chairman and professor, Department of Microbiology & Immunology, Medical University of South Carolina(MUSC)

l        Program Leader, Cancer Immunology Program, Hollings Cancer Center

l        The Abney Distinguished Endowed Chair in Stem Cell Biology

l        Faculty Member, Biomedical Science Graduate Program, MUSC

l        Attending Physician(Hematology/oncology), Division of Hematology and Oncology, Department of Medicine, MUSC Hospital, Charleston, SC

主持人： 邱晓彦教授

时  间： 2013 年 10 月 8 日 9:30

地  点：生化楼三楼中厅

主办单位：北京大基础医学院，免疫学系

报告人简介：

Dr. Zihai Li obtained his Ph.D. in immunology from the Mount Sinai School of Medicine in New York, followed by completing his clinical training in internal medicine at the Albert Einstein College of Medicine, New York, and in medical oncology at the Fred Hutchinson Cancer Research Center and University of Washington, Seattle .

His laboratory is primarily interested in the mechanism of immune regulation by the innate immune system in the context of cancer, infection and autoimmune disease. His research team has made seminal contributions to understanding the immunological properties of heat shock proteins (HSPs) in cancer immunotherapy and immune tolerance. They discovered that HSP gp 96 in the endoplasmic reticulum is the master molecular chaperone for Toll-like receptors (TLRs). They have uncovered several crucial aspects of the molecular mechanism of gp 96 in folding TLRs, including successful mapping of the TLR-binding domain of gp96 and definition of the elusive co-chaperone in the process.

Recently, his laboratory has also developed interests in the biology and application of stem cells including pluripotent stem cells and adult stem cells in cancer, as well as in inflammation and tissue repair.  

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