报告人：张彦斌 Yanbin Zhang, Ph.D. 

 Tenure-track Assistant Professor,

Department of Biochemistry & Molecular Biology,

University of Miami School of Medicine

主持人：朱卫国 教授 （北京大学基础医学院生物化学与分子生物学系）

时　间：  2009年10月27 日(周二) PM 14：30-15：30

地　点：生化楼三层中厅    

计继续教育学分1分，欢迎大家踊跃参与！                   北京大学基础医学院

                                                                2009.10.20

Yanbin Zhang （Ph.D.） is a tenure-track Assistant Professor at Department of Biochemistry & Molecular Biology, University of Miami School of Medicine. He got his PhD degree in Peking University in 1998, later he completed his postdoctoral training in the University of Kentucky. His research mainly focuses on two DNA repair mechanisms: interstrand cross-link (ICL) repair and mismatch repair (MMR), both of them safeguard genome from almost all unfavorable DNA modifications that initiate cancers.

 

Publication list (selected) (* denotes corresponding author):

1.       Yuan, F., et.al and Zhang, Y.*, FANCI proteins binds to DNA and interacts with FANCD2 to recognize branched structures. J. Biol. Chem. (2009) 284 (36): 24443-24452

2.       Zhang, Y., et.al. Identification of regulatory factor X as a novel mismatch repair stimulatory factor.  J. Biol. Chem. (2008) 283 (19): 12730-12735.

3.       Zhang, Y., et.al. Reconstitution of 5’-directed human mismatch repair in a purified system. Cell (2005) 122 (5): 693-705.

4.       Zhang, Y., et.al. Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucleic Acids Res. (2002) 30 (7): 1630-1638.

5.       Zhang, Y., et.al. Highly frequent frameshift DNA synthesis by human DNA polymerase mu. Mol. Cell. Biol. (2001) 21 (23): 7995-8006.

6.       Zhang, Y., et.al. Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity. Nucleic Acids Res. (2000) 28 (21): 4147-4156.

7.     Zhang, Y., et.al. Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro. Nucleic Acids Res. (2000) 28 (21): 4138-4146.

8.       Zhang, Y.,et.al. Preferential incorporation of G opposite template T by the low fidelity human DNA polymerase iota. Mol. Cell. Biol. (2000) 20 (19): 7099-7108.